December 7, 2021
October 26, 2021
Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs
DownloadNovember 24, 2020
Adoptive transfer of T cells surface-tethered with IL-12 promotes antigen spreading for enhanced anti-tumor efficacy
DownloadNovember 19, 2020
PRIME™ IL-15 (RPTR-147): Preliminary clinical results and biomarker analysis from a first-in-human Phase 1 study of IL-15 loaded peripherally-derived autologous T cell therapy in solid tumor patients
DownloadOctober 20, 2020
Deep TLR PrimedTM T cells induce potent anti-tumor activity without systemic toxicity
DownloadOctober 18, 2020
Adoptive Transfer of Deep IL-12 Primed™ T-cells Increases Sensitivity to PD-L1 Blockade for Superior Efficacy in Checkpoint Refractory Tumors
DownloadOctober 15, 2020
Delivery of TLR7 agonists by Deep-Primed™ T cells induces immune activation and improves anti-tumor activity in mice while circumventing systemic toxicity
DownloadOctober 13, 2020
Optimized process for manufacturing Deep-Primed™ T cells creates product with improved functional characteristics and reactivity against multiple tumor-associated antigens
DownloadOctober 12, 2020
Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors
DownloadOctober 11, 2020
DeepTM IL-15 primed T cells synergize with PD-L1 blockade to overcome resistance to checkpoint immunotherapy
DownloadOctober 8, 2020
DeepTM IL-15 Primed multi-targeted T cells demonstrate potent antigen-specific cytotoxic activity against human cancer cells
DownloadOctober 6, 2020
Surface-tethered IL-12 improves tumor-specific T cell therapy and enhances inflammatory activity in tumors without inducing systemic toxicities
DownloadOctober 1, 2020
Tethering IL-12 to the surface of T cells induces broad immune activation and potent anti-tumor activity in mice without inducing systemic toxicities
DownloadSeptember 29, 2020
Preclinical evaluation of Deep™ IL-15 Primed PMEL cells demonstrates highly improved safety compared to systemic administration of IL-15
DownloadSeptember 28, 2020
An Effective COVID-19 Vaccine Needs to Engage T Cells
DownloadSeptember 22, 2020
A fully-closed, high efficiency manufacturing technology platform for the production of T cell therapies targeting multiple tumor antigens
DownloadSeptember 15, 2020
T cell priming with Deep™ IL-15 improves preclinical safety compared to systemic IL-15, and increases in vivo persistence and activity
DownloadSeptember 8, 2020
Enhancing T cell therapy through TCR-signalingresponsive nanoparticle drug delivery
DownloadSeptember 1, 2020
DeepTM IL-15 provides autocrine stimulation and expansion of autologous T cells driven by controlled concentrated release of IL-15
DownloadAugust 25, 2020
Cell therapy with surface-tethered IL-12 provides immune system priming and strong anti-tumor activity
DownloadAugust 18, 2020
T cell receptor signaling-responsive single chain IL-12 and IL-15 superagonist nanogel “backpacks” to enhance adoptive cell therapy in solid tumors
DownloadAugust 11, 2020
Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells
DownloadAugust 4, 2020
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles
DownloadAugust 1, 2020