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From immune codes to immune medicines

Harnessing the power of the human immune system to understand and design precision immune medicines.

Our Science Decoding with purpose, deploying with precision.

While the immune system is the most complex and fine-tuned internal ‘medicine-producing’ engine ever created, harnessing its power to prevent and treat disease remains a new frontier. The key to the next generation of immune medicines lies in understanding the inner workings of the immune synapse – the interaction between T cells and antigen presenting cells – and an individual’s associated T cell “repertoire.”

Through its deep understanding of cellular immunity, Repertoire is designing a new class of precision immune medicines based on a novel strategy:

  • Decoding with purpose. Learning the language of our immune codes to detect and isolate relevant T cells based on their reactivity and specificity to disease-causing antigens.
  • Deploying with precision. Using this knowledge to design novel immune medicines for different kinds of cancer, autoimmune disorders and infectious diseases.

Unlocking the power of immune codes to create precision immune medicines

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Decode Integrated Discovery Platform Discover relevant TCR/Antigen pairs to inform precision drug development
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Deploy Product Development Engine Deliver multi-clonal therapeutics to enhance or moderate immune responses

Fully integrated immune discovery and therapeutics

  • Proprietary Antigen and TCR Discovery Technologies
  • Advanced T Cell Clonotype Analytics
  • Proven T Cell, Protein, and Nano Development & Proprietary GMP Manufacturing
  • Translational Medicine Expertise and Iterative Clinical Trials


At Repertoire, our goal is simple – harness the intrinsic ability of the immune synapse to prevent and cure disease. This mission is a challenging one, requiring a complex and multi-dimensional approach that integrates cutting-edge biology and sophisticated, novel technologies. We stand ready to meet this challenge with our unique platforms, our focused and proven team, and our unsurpassed network of researchers, clinicians, academics and entrepreneurs.

Board of Directors

Noubar Afeyan, Ph.D. Founder and Chief Executive Officer of Flagship Pioneering, Co-founder of Repertoire
Pablo Cagnoni, M.D., Ph.D. Board Member of Repertoire
Doug Cole, M.D. Managing Partner of Flagship Pioneering and Chairman of the Board of Repertoire
John Cox, M.B.A. Chief Executive Officer and Board Member of Repertoire
JC Gutierrez-Ramos, Ph.D. Board Member of Repertoire, Founding CEO
Steve Harr, M.D. Board Member of Repertoire

Professors in Residence

Thomas Andresen, Ph.D.
Christophe Benoist, Ph.D.
Arup Chakraborty, Ph.D.
Darrell Irvine, PH.D.
Manfred Kopf, Ph.D.
Doug Lauffenburger, Ph.D.
Alex Shalek, Ph.D.
David Spriggs, M.D., Ph.D.


A meaningful shift in the landscape of immune medicines requires the right people – an innovative team with the right ideas, drive and ability to execute on our shared vision. This is the team we are building at Repertoire. We are continually looking for the best and the brightest and recruit those whose own passion and ambition will contribute to fulfilling our mission.

Open Positions